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Jack R Harkema Selected Research

Metaplasia

4/2020MyD88 regulates a prolonged adaptation response to environmental dust exposure-induced lung disease.
12/2019Innate Lymphoid Cell-Dependent Airway Epithelial and Inflammatory Responses to Inhaled Ozone: A New Paradigm in Pathogenesis.
10/2019Role of chemical composition and redox modification of poorly soluble nanomaterials on their ability to enhance allergic airway sensitisation in mice.
1/2017Strain Differences in a Murine Model of Air Pollutant-induced Nonatopic Asthma and Rhinitis.
1/2017Innate Lymphoid Cells Mediate Pulmonary Eosinophilic Inflammation, Airway Mucous Cell Metaplasia, and Type 2 Immunity in Mice Exposed to Ozone.
3/2016Ozone-Induced Type 2 Immunity in Nasal Airways. Development and Lymphoid Cell Dependence in Mice.
1/2016Ozone-Induced Nasal Type 2 Immunity in Mice Is Dependent on Innate Lymphoid Cells.
11/2015Inhalation exposure to ethylene induces eosinophilic rhinitis and nasal epithelial remodeling in Fischer 344 rats.
7/2013Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice.
4/2010The effects of targeted deletion of cannabinoid receptors CB1 and CB2 on intranasal sensitization and challenge with adjuvant-free ovalbumin.
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Jack R Harkema Research Topics

Disease

54Inflammation (Inflammations)
11/2022 - 01/2002
20Metaplasia
04/2020 - 06/2002
18Asthma (Bronchial Asthma)
03/2022 - 04/2003
13Pneumonia (Pneumonitis)
03/2022 - 02/2002
11Glomerulonephritis
01/2021 - 01/2015
10Rhinitis
10/2020 - 01/2007
8Necrosis
11/2020 - 01/2007
7Lung Injury
11/2022 - 08/2010
6Autoimmune Diseases (Autoimmune Disease)
01/2021 - 01/2016
6Allergic Rhinitis
12/2019 - 06/2002
6Hypoxia (Hypoxemia)
01/2015 - 11/2008
5Fibrosis (Cirrhosis)
11/2020 - 02/2010
5Hyperplasia
10/2020 - 10/2011
4Systemic Lupus Erythematosus (Libman-Sacks Disease)
01/2021 - 01/2015
4Hypertrophy
10/2020 - 03/2010
4Neoplasms (Cancer)
01/2019 - 06/2007
4Lung Diseases (Lung Disease)
03/2014 - 05/2004
3Tertiary Lymphoid Structures
01/2021 - 01/2015
3Body Weight (Weight, Body)
12/2016 - 08/2007
3Fatty Liver
12/2016 - 06/2005
3Insulin Resistance
01/2016 - 01/2014
3Infections
11/2011 - 11/2006
2Chronic Bronchitis
04/2020 - 08/2004
2Chronic Obstructive Pulmonary Disease (COPD)
01/2020 - 04/2008
2Nephritis
01/2020 - 01/2019
2Weight Loss (Weight Reduction)
01/2019 - 01/2016
2Dyslipidemias (Dyslipidemia)
01/2018 - 12/2011
2Disease Progression
11/2017 - 08/2010
2Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2017 - 01/2014
2Non-alcoholic Fatty Liver Disease
12/2016 - 12/2016
2Atherosclerosis
10/2014 - 06/2004
2Cystic Fibrosis (Mucoviscidosis)
04/2013 - 05/2004
2Eosinophilia
03/2012 - 04/2010
2Human Influenza (Influenza)
11/2011 - 03/2008
1Neuroinflammatory Diseases
01/2022
1Mitochondrial Diseases (Mitochondrial Disease)
12/2021

Drug/Important Bio-Agent (IBA)

25OzoneIBA
11/2022 - 01/2002
18CytokinesIBA
03/2022 - 04/2003
14Particulate MatterIBA
03/2022 - 08/2004
12Proteins (Proteins, Gene)FDA Link
11/2022 - 07/2008
12Silicon Dioxide (Silica)FDA LinkGeneric
01/2021 - 01/2015
10Air Pollutants (Pollutants, Air)IBA
03/2022 - 05/2010
9Polychlorinated Dibenzodioxins (TCDD)IBA
08/2021 - 06/2005
8AllergensIBA
03/2014 - 02/2004
7AutoantibodiesIBA
01/2021 - 01/2018
6Messenger RNA (mRNA)IBA
12/2021 - 06/2004
6Immunoglobulin E (IgE)IBA
04/2020 - 07/2003
6Oxygen (Dioxygen)IBA
05/2018 - 11/2008
5ChemokinesIBA
03/2022 - 01/2019
5LipopolysaccharidesIBA
08/2021 - 08/2007
5Docosahexaenoic AcidsIBA
01/2021 - 01/2018
5Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
01/2021 - 01/2018
5EndotoxinsIBA
03/2014 - 01/2002
4Environmental Pollutants (Pollutants, Environmental)IBA
03/2022 - 08/2004
4Oxidants (Oxidizing Agents)IBA
10/2021 - 10/2007
4AerosolsIBA
10/2021 - 06/2003
4InterferonsIBA
01/2021 - 01/2020
4Biological ProductsIBA
01/2020 - 08/2010
4DNA (Deoxyribonucleic Acid)IBA
01/2017 - 02/2004
4OvalbuminIBA
03/2012 - 04/2003
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2012 - 02/2002
3SootIBA
12/2021 - 01/2020
3CollagenIBA
11/2020 - 12/2016
3Interleukin-13IBA
11/2020 - 04/2008
3SmogIBA
01/2017 - 02/2011
3Interleukin-6 (Interleukin 6)IBA
12/2016 - 02/2007
3Glucose (Dextrose)FDA LinkGeneric
12/2016 - 01/2014
3Interleukin-5 (Interleukin 5)IBA
03/2016 - 06/2004
3LipidsIBA
12/2015 - 01/2014
3Transcription Factors (Transcription Factor)IBA
01/2015 - 11/2008
3CobaltIBA
02/2014 - 02/2010
3Alanine Transaminase (SGPT)IBA
10/2013 - 12/2011
3MycotoxinsIBA
07/2008 - 11/2006
2CarbonIBA
10/2021 - 12/2016
2RNA (Ribonucleic Acid)IBA
01/2021 - 01/2020
2Hydroxyproline (4 Hydroxyproline)IBA
11/2020 - 11/2017
2ethyleneIBA
10/2020 - 11/2015
2Immunoglobulin G (IgG)IBA
10/2019 - 01/2015
2Insulin (Novolin)FDA Link
01/2016 - 01/2014
2Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
12/2015 - 12/2011
2Therapeutic UsesIBA
03/2014 - 10/2007
2AntioxidantsIBA
03/2014 - 10/2007
2satratoxin GIBA
08/2012 - 07/2006
2Cannabinoid Receptors (Cannabinoid Receptor)IBA
11/2011 - 03/2008
22,4,5,2',4',5'-hexachlorobiphenylIBA
10/2011 - 03/2010
2SmokeIBA
08/2010 - 06/2009
2Phenobarbital (Luminal)FDA Link
04/2010 - 08/2004
2ChitinasesIBA
02/2010 - 04/2008
2MucinsIBA
11/2009 - 04/2008
2gamma-TocopherolIBA
06/2009 - 10/2007
2trichotheceneIBA
08/2007 - 11/2006
2trimellitic anhydrideIBA
07/2006 - 06/2004
1Platelet Endothelial Cell Adhesion Molecule-1IBA
01/2022
1Adenosine Triphosphate (ATP)IBA
12/2021
1CatalaseIBA
10/2021
1Superoxide DismutaseIBA
10/2021
1AlarminsIBA
10/2021
1Fenofibrate (CiL)FDA LinkGeneric
08/2021
1GalactosamineIBA
08/2021

Therapy/Procedure

4Therapeutics
04/2008 - 05/2004